Sampling and Sample Preparation for Chromatography
Course Format:
This course is 1.5 days, held in-person at the Heritage Center of Brooklyn Center. It will be all day on Tuesday, June 10 and half day on Wednesday, June 11.
Course Description:
This short course is designed to provide participants with an in-depth understanding of the role of sampling and sample preparation in analytical chemistry, especially as related to chromatography, and an overview of sample preparation techniques and strategies. Throughout the course practical and theoretical aspects of the outlined topics and application case studies will be presented.
Topics (Sample Outline):
This course is 1.5 days, held in-person at the Heritage Center of Brooklyn Center. It will be all day on Tuesday, June 10 and half day on Wednesday, June 11.
Course Description:
This short course is designed to provide participants with an in-depth understanding of the role of sampling and sample preparation in analytical chemistry, especially as related to chromatography, and an overview of sample preparation techniques and strategies. Throughout the course practical and theoretical aspects of the outlined topics and application case studies will be presented.
Topics (Sample Outline):
- Introduction
- Why sample preparation
- Sample preparation trends
- Sampling and Sample Considerations
- Types of samples
- Sampling statistics
- Reduction of sample size and particle size
- General Extraction Considerations
- Physical parameters
- Classification of extraction methods
- Extraction kinetics
- Extraction from Liquid Samples
- Distribution ratio
- Liquid-liquid extraction
- Solvent selection, including green solvents
- Microscale methods
- Solid-phase extraction
- QuECHERS
- Solid-phase microextraction
- Other sorbent- and membrane-based methods
- Extraction from Solid Samples
- Soxhlet extraction
- Accelerated solvent extraction
- Supercritical fluid extraction
- Microwave-assisted extraction
- Ultrasound extraction
- Tissue Extractions
- Extraction of Volatile Analytes
- Static and Dynamic headspace sampling
- Purge and trap
- Post-Extraction Sample Handling
- Solvent evaporation
- Sample derivatization
Instructor Bio: Dr. Douglas Raynie, Ph.D.
Professor Emeritus, Department of Chemistry, Biochemistry and Physics, South Dakota State University
Dr. Douglas Raynie is Professor Emeritus in the Department of Chemistry, Biochemistry and Physics at South Dakota State University. Prior to joining SDSU, he was employed for eleven years as a Senior Scientist at Procter and Gamble's Corporate Research Division. He earned his Ph.D. at Brigham Young University under the direction of Dr. Milton L. Lee. Dr. Raynie’s research interests include high-resolution chromatography (including high-temperature LC and SFC), chromatographic sample preparation (including ASE, SFE, SPME, and SPE), chromatography theory, green chemistry, and problem-based learning in analytical chemistry. He was the long-time author of the Sample Preparation Perspectives column for LC/GC and serves on the editorial advisory boards of LC/GC International and Separations. The Minnesota Chromatography Forum recognized Raynie with the L.S. Palmer Award in 2019.
Professor Emeritus, Department of Chemistry, Biochemistry and Physics, South Dakota State University
Dr. Douglas Raynie is Professor Emeritus in the Department of Chemistry, Biochemistry and Physics at South Dakota State University. Prior to joining SDSU, he was employed for eleven years as a Senior Scientist at Procter and Gamble's Corporate Research Division. He earned his Ph.D. at Brigham Young University under the direction of Dr. Milton L. Lee. Dr. Raynie’s research interests include high-resolution chromatography (including high-temperature LC and SFC), chromatographic sample preparation (including ASE, SFE, SPME, and SPE), chromatography theory, green chemistry, and problem-based learning in analytical chemistry. He was the long-time author of the Sample Preparation Perspectives column for LC/GC and serves on the editorial advisory boards of LC/GC International and Separations. The Minnesota Chromatography Forum recognized Raynie with the L.S. Palmer Award in 2019.