Sampling and Sample Preparation for Chromatography
Course Format: This course is 1.5 days, held in-person at the Heritage Center of Brooklyn Center. It will be all day on Tuesday, June 10 and half day on Wednesday, June 11. Course Description: This short course is designed to provide participants with an in-depth understanding of the role of sampling and sample preparation in analytical chemistry, especially as related to chromatography, and an overview of sample preparation techniques and strategies. Throughout the course practical and theoretical aspects of the outlined topics and application case studies will be presented.
Topics (Sample Outline):
Introduction
Why sample preparation
Sample preparation trends
Sampling and Sample Considerations
Types of samples
Sampling statistics
Reduction of sample size and particle size
General Extraction Considerations
Physical parameters
Classification of extraction methods
Extraction kinetics
Extraction from Liquid Samples
Distribution ratio
Liquid-liquid extraction
Solvent selection, including green solvents
Microscale methods
Solid-phase extraction
QuECHERS
Solid-phase microextraction
Other sorbent- and membrane-based methods
Extraction from Solid Samples
Soxhlet extraction
Accelerated solvent extraction
Supercritical fluid extraction
Microwave-assisted extraction
Ultrasound extraction
Tissue Extractions
Extraction of Volatile Analytes
Static and Dynamic headspace sampling
Purge and trap
Post-Extraction Sample Handling
Solvent evaporation
Sample derivatization
Instructor Bio: Dr. Douglas Raynie, Ph.D. Professor Emeritus, Department of Chemistry, Biochemistry and Physics, South Dakota State University Dr. Douglas Raynie is Professor Emeritus in the Department of Chemistry, Biochemistry and Physics at South Dakota State University. Prior to joining SDSU, he was employed for eleven years as a Senior Scientist at Procter and Gamble's Corporate Research Division. He earned his Ph.D. at Brigham Young University under the direction of Dr. Milton L. Lee. Dr. Raynie’s research interests include high-resolution chromatography (including high-temperature LC and SFC), chromatographic sample preparation (including ASE, SFE, SPME, and SPE), chromatography theory, green chemistry, and problem-based learning in analytical chemistry. He was the long-time author of the Sample Preparation Perspectives column for LC/GC and serves on the editorial advisory boards of LC/GC International and Separations. The Minnesota Chromatography Forum recognized Raynie with the L.S. Palmer Award in 2019.